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Mepivacaine vs. Bupivacaine for Knee Replacement Surgery

N/A
Recruiting
Led By Clinton Pillow, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within past 90 days at time of procedure
Awards & highlights

Study Summary

This trial will compare two spinal blocks to see which leads to faster recovery of motor function after total knee replacement. Faster movement and discharge times may result.

Who is the study for?
This trial is for individuals aged 18-75 who are scheduled to have an elective primary total knee replacement. It's not suitable for those outside this age range or having different types of knee surgeries.Check my eligibility
What is being tested?
The study compares two spinal blocks, mepivacaine and bupivacaine, in patients undergoing knee replacement surgery. The aim is to see which one allows patients to recover motor function faster, potentially leading to quicker movement and discharge.See study design
What are the potential side effects?
Possible side effects from the spinal blocks may include low blood pressure, headaches, back pain, nausea or difficulty urinating. These are common risks associated with spinal anesthesia but can vary between individuals.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within past 90 days at time of procedure
This trial's timeline: 3 weeks for screening, Varies for treatment, and within past 90 days at time of procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time until return of motor function following spinal placement
Secondary outcome measures
Ambulation
Length of Stay
Pain Scores
+1 more
Other outcome measures
Cement use
Preoperative opioid use
Robotic or not
+1 more

Trial Design

2Treatment groups
Active Control
Group I: Mepivacaine SpinalActive Control1 Intervention
Mepivacaine (60 mg: 3ml of 2%) or will be injected into the intrathecal space.
Group II: Bupivacaine SpinalActive Control1 Intervention
Isobaric bupivacaine (10mg: 2ml or 0.5%) will be injected into the intrathecal space.

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
937 Previous Clinical Trials
7,396,690 Total Patients Enrolled
Clinton Pillow, MDPrincipal InvestigatorMedical University of South Carolina

Media Library

Bupivacaine Spinal Clinical Trial Eligibility Overview. Trial Name: NCT05765682 — N/A
Total Knee Arthroplasty Research Study Groups: Mepivacaine Spinal, Bupivacaine Spinal
Total Knee Arthroplasty Clinical Trial 2023: Bupivacaine Spinal Highlights & Side Effects. Trial Name: NCT05765682 — N/A
Bupivacaine Spinal 2023 Treatment Timeline for Medical Study. Trial Name: NCT05765682 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are seniors excluded from participating in this clinical experiment?

"This medical research is open to individuals older than the age of consent and younger than 75 years old."

Answered by AI

Are additional participants being sought for this research endeavor?

"Affirmative. Clinicaltrials.gov data shows that this clinical experiment, first posted on March 13th 2023, is actively recruiting volunteers for participation. The trial has the goal of enrolling 160 patients from a single site."

Answered by AI

How many applicants are being accepted into this clinical research experiment?

"Indeed, the details on clinicaltrials.gov verify that this experiment is recruiting participants as of now. It was initially posted on March 13th 2023 and has recently been updated on May 2nd 2023. The research team aims to enroll 160 individuals across one medical facility."

Answered by AI

Might I obtain admittance to this experiment?

"This medical study seeks 160 participants who have undergone total knee arthroplasty, and are aged between 18-75."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Mepivacaine vs. Bupivacaine Spinal for TKA
Clinton F. Pillow 2023. "Mepivacaine vs. Bupivacaine Spinal for TKA". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05765682.
~19 spots leftby Aug 2024
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