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Adapted Cognitive Processing Therapy for PTSD (CPT MOST Trial)
N/A
Recruiting
Led By Rebecca Kaufman Sripada, PhD MS
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6-week, 3-month, 6-month
Awards & highlights
CPT MOST Trial Summary
This trial will test a brief, effective form of CPT against a control condition.
Who is the study for?
This trial is for Veterans over 18 with PTSD treated in PCTs, stable on psychotropic meds for at least 8 weeks, and scoring above 33 on the PCL-5. It's not for those with severe cognitive issues, psychosis or unmanaged bipolar disorder, recent CPT treatment, current detox needs, ongoing trauma-focused therapy, or acute suicide risk.Check my eligibility
What is being tested?
The study aims to adapt Cognitive Processing Therapy (CPT) into a shorter format by identifying and delivering only its most effective components. This could reduce dropouts due to time constraints or lack of benefit and ensure that Veterans receive the best parts of CPT more efficiently.See study design
What are the potential side effects?
While specific side effects are not listed here as it's a psychological intervention rather than a drug trial, participants may experience emotional discomfort when discussing traumatic events during therapy sessions.
CPT MOST Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 6-week, 3-month, 6-month
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6-week, 3-month, 6-month
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Change
Secondary outcome measures
PTSD Checklist for DSM-5 (PCL-5) Change
Patient Health Questionnaire (PHQ-9) Change
CPT MOST Trial Design
16Treatment groups
Active Control
Group I: 4Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Module Choice, Final Session
Group II: 14Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Problematic Patterns, Challenging Beliefs, Final Session
Group III: 10Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C , Challenging Beliefs, Module Choice, Final Session
Group IV: 13Active Control3 Interventions
Core Session 1, Core Session 2, Problematic Patterns, Challenging Beliefs, Module Choice, Final Session
Group V: 16Active Control5 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Problematic Patterns, Challenging Beliefs, Module Choice, Final Session
Group VI: 11Active Control3 Interventions
Core Session 1, Core Session 2, Challenging Questions, Challenging Beliefs, Module Choice, Final Session
Group VII: 7Active Control3 Interventions
Core Session 1, Core Session 2, Challenging Questions, Problematic Patterns, Module Choice, Final Session
Group VIII: 2Active Control1 Intervention
Core Session 1, Core Session 2, Modified A-B-C, Final Session
Group IX: 3Active Control1 Intervention
Core Session 1, Core Session 2, Challenging Questions, Final Session
Group X: 5Active Control1 Intervention
Core Session 1, Core Session 2, Problematic Patterns, Final Session
Group XI: 6Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Problematic Patterns, Module Choice, Final Session
Group XII: 8Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Problematic Patterns, Final Session
Group XIII: 9Active Control1 Intervention
Core Session 1, Core Session 2, Challenging Beliefs, Final Session
Group XIV: 12Active Control3 Interventions
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Challenging Beliefs, Final Session
Group XV: 15Active Control3 Interventions
Core Session 1, Core Session 2, Challenging Questions, Problematic Patterns, Challenging Beliefs, Final Session
Group XVI: 1Active Control1 Intervention
Core Session 1, Core Session 2, Module Choice, Final Session
Find a Location
Who is running the clinical trial?
VA Office of Research and DevelopmentLead Sponsor
1,618 Previous Clinical Trials
3,315,903 Total Patients Enrolled
Rebecca Kaufman Sripada, PhD MSPrincipal InvestigatorVA Ann Arbor Healthcare System, Ann Arbor, MI
1 Previous Clinical Trials
39 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I am currently in therapy for trauma (PE or CPT).I am over 18 years old.I have been on the same dose of my mental health medication for at least 8 weeks.I have received CPT treatment within the last year.I am able to understand and follow the study's requirements.I am a veteran with PTSD receiving care from a specialized team.
Research Study Groups:
This trial has the following groups:- Group 1: 4
- Group 2: 14
- Group 3: 10
- Group 4: 13
- Group 5: 16
- Group 6: 11
- Group 7: 7
- Group 8: 2
- Group 9: 3
- Group 10: 5
- Group 11: 6
- Group 12: 8
- Group 13: 9
- Group 14: 12
- Group 15: 15
- Group 16: 1
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any vacancies available for those wishing to take part in this investigation?
"Affirmative, according to the information available via clinicaltrials.gov, this trial is actively enrolling patients. It was first posted on August 1st of 2022 and recently updated on August 3rd; 270 participants are being sought across three sites."
Answered by AI
How many participants are being enrolled in this investigation?
"Affirmative. According to clinicaltrials.gov, this experiment is actively seeking candidates and was first posted on August 1st 2022 with the latest alteration having been made on August 3rd of the same year. 270 individuals are required between 3 sites for enrollment in this study."
Answered by AI
Who else is applying?
What state do they live in?
Utah
How old are they?
18 - 65
What site did they apply to?
VA Salt Lake City Health Care System, Salt Lake City, UT
What portion of applicants met pre-screening criteria?
Met criteria
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