← Back to Search

Routine PT for Respiratory Failure (CYCLE Trial)

N/A
Waitlist Available
Led By Michelle Kho, PT, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up icu awakening, approximately 6 days after icu admission; icu discharge, approximately 12 days after icu admission; 3 days after icu discharge; hospital discharge, approximately 28 days after icu admission
Awards & highlights

CYCLE Trial Summary

This trial is testing whether in-bed cycling can help people recover from being critically ill.

Who is the study for?
This trial is for adults over 18 in the ICU, on mechanical ventilation for ≤4 days, and expected to stay at least 2 more days. They must have been able to walk independently before ICU admission. Exclusions include severe cognitive issues pre-ICU, certain acute conditions, pregnancy, high risk of hospital mortality, or if equipment doesn't fit due to body size.Check my eligibility
What is being tested?
The CYCLE trial tests if early in-bed cycling combined with routine physiotherapy helps critically ill patients on ventilators recover faster than just routine physiotherapy. Patients are randomly assigned to one of these two groups and their strength and physical function are monitored.See study design
What are the potential side effects?
While specific side effects aren't listed here, potential risks may include muscle soreness or fatigue from the exercise intervention. The study will monitor patients closely for any adverse reactions related to the in-bed cycling.

CYCLE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~icu awakening, approximately 6 days after icu admission; icu discharge, approximately 12 days after icu admission; hospital discharge, approximately 28 days after icu admission
This trial's timeline: 3 weeks for screening, Varies for treatment, and icu awakening, approximately 6 days after icu admission; icu discharge, approximately 12 days after icu admission; hospital discharge, approximately 28 days after icu admission for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
30 Second Sit to Stand
Clinical Frailty Scale
Duration of Mechanical Ventilation
+14 more

CYCLE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: In-Bed Cycle Ergometer + Routine PTExperimental Treatment2 Interventions
Patients will receive 30 minutes of in-bed cycling once per day, 5 days per week, while they remain in the ICU, for up to a maximum of 28 days. They will also receive routine physiotherapy.
Group II: Routine PTActive Control1 Intervention
Patients will receive routine physiotherapy interventions per current institutional practice

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
886 Previous Clinical Trials
2,598,112 Total Patients Enrolled
2 Trials studying Respiratory Failure
146 Patients Enrolled for Respiratory Failure
St. Joseph's Healthcare HamiltonOTHER
196 Previous Clinical Trials
25,188 Total Patients Enrolled
3 Trials studying Respiratory Failure
246 Patients Enrolled for Respiratory Failure
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,345 Previous Clinical Trials
26,453,154 Total Patients Enrolled
1 Trials studying Respiratory Failure
113 Patients Enrolled for Respiratory Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
TrialsJournal
Research Interrupted: Applying the CONSERVE 2021 Statement to a Randomized Trial of Rehabilitation During Critical Illness Affected by the COVID-19 Pandemic
Reid, Julie C., Alex Molloy, Geoff Strong, Laurel Kelly, Heather O’Grady, Deborah Cook, Patrick M. Archambault, et al.. 2022. “Research Interrupted: Applying the CONSERVE 2021 Statement to a Randomized Trial of Rehabilitation During Critical Illness Affected by the COVID-19 Pandemic”. Trials. Springer Science and Business Media LLC. doi:10.1186/s13063-022-06640-y.
clinicaltrials.govStudy
CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients
2018. "CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03471247.
~55 spots leftby May 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top