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Brachytherapy
Radiation Therapies for Prostate Cancer
N/A
Waitlist Available
Led By Peter Chung, MB ChB
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
Study Summary
This trial is testing whether or not delivering radiation to a specific area in the prostate, as seen on MRI, at a higher than normal dose is safe and effective.
Who is the study for?
This trial is for men with prostate cancer who have a life expectancy of over 10 years and are fit (ECOG status 0 or 1). They must have visible tumors on MRI, be at least 18 years old, and not exceed a weight of 136kg due to scanner limits. Men with pacemakers or certain metal implants cannot participate. Those currently on hormone therapy or with other cancers in the last five years are also excluded.Check my eligibility
What is being tested?
The study tests high-dose radiation targeting tumor nodules within the prostate gland using MRI guidance. It aims to see if delivering higher doses directly to the tumor can prevent cancer from remaining or returning after standard treatments like surgery, EBRT, or brachytherapy.See study design
What are the potential side effects?
While specific side effects aren't listed here, high-dose radiation may cause urinary issues, bowel problems such as diarrhea and discomfort, fatigue, sexual dysfunction, and skin irritation around the treated area.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Determine rates of Local Control after standard targeted boost radiotherapy in patients with localized prostate cancer.
Secondary outcome measures
Assess Quality of Life (QoL) outcomes after high-dose tumor-targeted boost therapy.
Compare dose to recurrent and non-recurrent tumor nodules.
Determine a methodology with appropriate uncertainty margins for Gross Tumour Volume boost
+6 moreOther outcome measures
Biopsy
Explore the predictive value of baseline and early response imaging biomarkers on Local Control.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Prior Radiation Treatment (Control Cohort)Experimental Treatment1 Intervention
Patients who received 78Gy RT to the prostate gland 3-4.5 years prior to enrollment. This group will not be receiving any active treatment
Group II: Active Radiation Treatment (Cohort 2)Experimental Treatment1 Intervention
Find a Location
Who is running the clinical trial?
University Health Network, TorontoLead Sponsor
1,482 Previous Clinical Trials
486,337 Total Patients Enrolled
63 Trials studying Prostate Cancer
15,315 Patients Enrolled for Prostate Cancer
Princess Margaret Hospital, CanadaOTHER
119 Previous Clinical Trials
38,974 Total Patients Enrolled
9 Trials studying Prostate Cancer
9,831 Patients Enrolled for Prostate Cancer
Peter Chung, MB ChBPrincipal InvestigatorUniversity Health Network, The Princess Margaret
3 Previous Clinical Trials
512 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have an allergy to latex.You have a history of certain diseases like Ulcerative Colitis, Crohn's Disease, Ataxia Telangiectasia, or SLE (Cohort 2).You were diagnosed with a type of cancer, other than skin cancer, within the last 5 years.You have a condition that makes you prone to bleeding and you are taking medication that prevents blood from clotting, which cannot be stopped temporarily before the biopsy.Before starting treatment, you need to have certain risk factors.You have received radiation treatment to the prostate in the past.You have a strong fear of enclosed spaces (like small rooms or MRI machines).
Research Study Groups:
This trial has the following groups:- Group 1: Active Radiation Treatment (Cohort 2)
- Group 2: Prior Radiation Treatment (Control Cohort)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this inquiry currently recruiting participants?
"Per clinicaltrials.gov, this medical study is not actively enrolling volunteers at the moment. Originally posted in October 1st 2012 and last updated on 20th 2022, it has ceased its recruitment process; however there are 1322 other trials that continue to search for participants."
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