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Aerobic Exercise for Post-Exercise Hypotension

Q: Is this clinical trial open to those aged eighty or above?

To be admitted into this study, candidates must be aged between 18 to 45. Conversely, there are 5 clinical trials available for minors and 94 studies open to seniors of 65 years or above.

Q: To whom does this trial offer enrollment opportunities?

To participate in this medical trial, individuals must meet two criteria: having post-exercise hypotension and being between the ages of 18 and 45. The enrollment target is 25 subjects.

Q: Are there any opportunities for enrolment in this clinical trial at present?

Data posted to clinicaltrials.gov reveals that the trial is actively seeking enrollees; it was introduced on April 1st 2023 and last modified a few weeks later, on April 18th of the same year.

N/A

Recruiting

Research Sponsored by University of Delaware

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 120 post-exercise

Awards & highlights

Study Summary

This trial looks at how exercise affects the heart & large leg arteries in healthy adults, using oral antihistamines & placebo pills.

Who is the study for?

This trial is for healthy young adults who are either not very active or exercise recreationally. They shouldn't have a history of heart problems, high blood pressure, metabolic or kidney diseases, respiratory issues, and must not be on any heart medications. Pregnant or breastfeeding individuals, tobacco users, those with certain musculoskeletal issues preventing cycling exercise, and people outside the BMI range of 18.5 to 35 are also excluded.Check my eligibility

What is being tested?

The study tests how moderate aerobic exercise like stationary biking affects heart function and blood vessels in the legs by measuring changes before and after exercising. It looks at whether these changes result from decreased stiffness in large arteries or increased leg blood flow. Participants will take antihistamines during one visit and placebo pills during another to see the difference.See study design

What are the potential side effects?

Potential side effects may include reactions to oral antihistamines such as drowsiness, dry mouth, dizziness or digestive discomfort since participants will be taking these drugs to block post-exercise dilation of their blood vessels.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 120 post-exercise

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~120 post-exercise

This trial's timeline: 3 weeks for screening, Varies for treatment, and 120 post-exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in left ventricular pulsatile load

Change in leg vascular conductance

Change in lower limb arterial stiffness

Secondary outcome measures

Change in left ventricular diastolic function

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: AntihistamineExperimental Treatment1 Intervention

The oral antihistamine condition will consist of fexofenadine (540mg) and famotidine (40mg). Commercially available pills (3 x 180mg fexofenadine and 2 x 20mg famotidine) will be placed within opaque capsules and administered to the participants upon arrival to the laboratory.

Group II: PlaceboPlacebo Group1 Intervention

The placebo condition will consist of dextrose in an identical number of opaque capsules as the antihistamine treatment. Total dextrose will be <5g. The capsules will be administered to the participants upon arrival to the laboratory.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of DelawareLead Sponsor

154 Previous Clinical Trials

25,062 Total Patients Enrolled

1 Trials studying Post-Exercise Hypotension

20 Patients Enrolled for Post-Exercise Hypotension

Media Library

Moderate Intensity Aerobic Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05820243 — N/A

Post-Exercise Hypotension Research Study Groups: Placebo, Antihistamine

Post-Exercise Hypotension Clinical Trial 2023: Moderate Intensity Aerobic Exercise Highlights & Side Effects. Trial Name: NCT05820243 — N/A

Moderate Intensity Aerobic Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05820243 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this clinical trial open to those aged eighty or above?

"To be admitted into this study, candidates must be aged between 18 to 45. Conversely, there are 5 clinical trials available for minors and 94 studies open to seniors of 65 years or above."

Answered by AI

To whom does this trial offer enrollment opportunities?

"To participate in this medical trial, individuals must meet two criteria: having post-exercise hypotension and being between the ages of 18 and 45. The enrollment target is 25 subjects."

Answered by AI

Are there any opportunities for enrolment in this clinical trial at present?

"Data posted to clinicaltrials.gov reveals that the trial is actively seeking enrollees; it was introduced on April 1st 2023 and last modified a few weeks later, on April 18th of the same year."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Determinants of Changes in Arterial Load Following Exercise

David Edwards 2023. "Determinants of Changes in Arterial Load Following Exercise". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05820243.