← Back to Search

Exercise Programs for Knee Arthritis

N/A
Recruiting
Led By Prakash Jayabalan, MD, PhD
Research Sponsored by Shirley Ryan AbilityLab
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8
Awards & highlights

Study Summary

This trial will compare 3 exercise protocols to see how they affect knee pain & joint function in people with knee pathology.

Who is the study for?
This trial is for individuals over 50 with knee osteoarthritis, able to walk unaided and have a Kellgren-Lawrence score of 2+ on knee radiographs. Excluded are those under 50, pregnant women, people with certain cardiovascular conditions or extreme body sizes, joint replacements, or neurological disorders affecting leg function.Check my eligibility
What is being tested?
The study compares three different 8-week exercise programs for knee osteoarthritis: standard treadmill/community walking, LBPP-supported low-load treadmill walking, and aquatic walking. It aims to assess their impact on serum biomarkers related to joint disease and thigh muscle strength.See study design
What are the potential side effects?
While not explicitly stated in the provided information, potential side effects from these exercises may include muscle soreness, joint pain flare-ups during initial adaptation periods or if improperly performed.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Cartilage oligomeric matrix protein (COMP) serum concentration
Pain subscore on the Knee injury and Osteoarthritis Score (KOOS Survey)
Secondary outcome measures
Analysis of cardiovascular parameters
Change in Cardiometabolic (serum adiponectin) concentrations
Change in Inflammatory cytokine (IL-1B) concentration
+8 more

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Intervention group 2: Aquatic Walking exerciseExperimental Treatment1 Intervention
Participants enrolled in the aquatic exercise program will complete a total of two aquatic walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Each aquatic exercise program will include walking in the pool for 30 minutes at self-selected speeds under the guidance of an aquatic therapy instructor. Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.
Group II: Intervention group 1: Lower-body positive-pressure supported low-load treadmill walking exerciseExperimental Treatment1 Intervention
Participants enrolled in the Lower-body positive-pressure (LBPP) supported low-load treadmill walking exercise will complete a total of two walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Each walking session will include 30-minute walking on a G-Trainer (AlterG Inc., Fremont, CA) under low-load walking conditions. Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.
Group III: Control group: Standard of care land-based walking exerciseActive Control1 Intervention
Participants enrolled in the land-based walking exercise program will complete a total of two community walking or normal treadmill (not LBPP) walking exercise sessions per week for a total of eight consecutive weeks (i.e. 16 exercise sessions in all). Apart from these exercise sessions participants in this group will complete 3 separate evaluation sessions at the beginning, interim, and end of the study where they will be walking on a standard-of care treadmill for 30 minutes with blood draws at 0 and 30 minutes (only during beginning and end session), kinematic measure of gait parameters, measures of different cardiovascular parameters and cardiometabolic markers followed by thigh muscle strength testing.

Find a Location

Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
200 Previous Clinical Trials
17,094 Total Patients Enrolled
1 Trials studying Rheumatic Diseases
28 Patients Enrolled for Rheumatic Diseases
Northwestern UniversityOTHER
1,601 Previous Clinical Trials
915,614 Total Patients Enrolled
2 Trials studying Rheumatic Diseases
88 Patients Enrolled for Rheumatic Diseases
Prakash Jayabalan, MD, PhDPrincipal InvestigatorShirley Ryan AbilityLab
3 Previous Clinical Trials
118 Total Patients Enrolled
1 Trials studying Rheumatic Diseases
28 Patients Enrolled for Rheumatic Diseases

Media Library

Exercise for Knee Osteoarthritis - (Aquatic Walking) Clinical Trial Eligibility Overview. Trial Name: NCT05844124 — N/A
~19 spots leftby May 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top