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Radiation Therapy
SABR for Cancer
N/A
Waitlist Available
Led By Robert Olson, MD
Research Sponsored by British Columbia Cancer Agency
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
ECOG performance status 0-2
All brain metastases cases need approval from Stereotactic Radiosurgery (SRS) rounds
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at approximately the end of year 5
Awards & highlights
Study Summary
This trial is testing a new cancer treatment and measuring its toxicity. There is potential for the treatment to improve survival for people with a certain type of cancer.
Who is the study for?
This trial is for people with a limited number of cancer spread sites (up to 5), who've had their primary tumor treated, and are not candidates for surgery. They should be in relatively good health otherwise, able to consent, and complete questionnaires in English. Pregnant women or those with certain medical conditions that make radiotherapy unsafe cannot join.Check my eligibility
What is being tested?
The study tests Stereotactic Ablative Body Radiotherapy (SABR) on patients with few metastatic cancer sites. It aims to assess the side effects and potential survival benefits of this targeted high-dose radiation therapy compared to other treatments.See study design
What are the potential side effects?
Potential side effects include skin reactions at the treatment site, fatigue, nausea, pain or swelling around the treated area. There may also be risks specific to where the SABR is directed; for example, lung inflammation if treating chest metastases.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I can take care of myself and am up and about more than half of the day.
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My brain metastases have been approved for treatment by a specialized team.
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I am not a candidate for surgery to remove my cancer as advised by my medical team.
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My cancer has spread, and this was confirmed by tests.
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My primary cancer was treated with intent to cure or controlled with prior therapy.
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My non-brain cancer spot is no larger than 3cm if treated with a single radiation dose.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at approximately the end of year 5
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at approximately the end of year 5
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Patient-reported Quality of life, function and health status using BC Cancer's Prospective Outcomes and Support Initiative (POSI).
Toxicity as Assessed by the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 4 for each organ treated (e.g. liver, lung, bone)]
Secondary outcome measures
Lesional control rate, defined as lack of further progression
Overall survival
Progression-free survival
Trial Design
1Treatment groups
Experimental Treatment
Group I: Stereotactic armExperimental Treatment1 Intervention
Stereotactic ablative radiotherapy
Find a Location
Who is running the clinical trial?
British Columbia Cancer AgencyLead Sponsor
171 Previous Clinical Trials
90,112 Total Patients Enrolled
Robert Olson, MDPrincipal InvestigatorBC Cancer Agency - Centre for the North
1 Previous Clinical Trials
204 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I can take care of myself and am up and about more than half of the day.My brain metastases have been approved for treatment by a specialized team.I only need a PET-CT or PSMA-PET scan for certain conditions.My cancer has spread, and this was confirmed by tests.I have signs of pressure on my spinal cord.I have had an MRI of the spine due to cancer spread to my spine or nearby.My first chemotherapy fully eliminated the cancer that can be measured.My cancer cannot be treated with the goal of removing it completely.My tumor is between 3.1 and 4cm, and I can consider a specific radiation dose.I haven't taken any chemotherapy drugs 2 weeks before or will not take them until 1 week after my radiation treatment.My cancer has fully responded to previous systemic therapy according to scans.I had a non-radiation treatment for my cancer and might have residual disease.I have not been treated with SABR for my current cancer sites.My cancer has spread to my thigh bone and there's a high risk it might break.I have 1-3 brain tumors and no cancer in other parts of my body.I need surgery to relieve pressure in my brain from cancer.I have not necessarily had a biopsy of my metastasis.My primary cancer was treated with intent to cure or controlled with prior therapy.I am not a candidate for surgery to remove my cancer as advised by my medical team.I have health conditions that prevent me from receiving radiation therapy.My non-brain cancer spot is no larger than 3cm if treated with a single radiation dose.All my cancer growths can be safely treated.I have had a CT scan of my chest, abdomen, and pelvis, or a PET-CT as required.My cancer outside the brain has lesions no larger than 6 cm, except for some bone metastases.I have up to 5 cancer spots that can be treated with targeted radiation.My previous radiation therapy allows for safe SABR treatment, approved by a medical team.I have ongoing fluid buildup due to cancer in the lining of my lung.I have had treatment for cancer that has spread.
Research Study Groups:
This trial has the following groups:- Group 1: Stereotactic arm
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does this research project continue to accept participants?
"It is evident from the data present on clinicaltrials.gov that this trial, which was initially posted in November 2016 and last updated in October 2022, has suspended its recruitment of patients. Nevertheless, there are 636 other trials being conducted at the moment that welcome new participants."
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