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Cardiac MRI Technique for Coronary Artery Disease (CATCH Trial)
N/A
Recruiting
Led By Debiao Li, PhD
Research Sponsored by Cedars-Sinai Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights
CATCH Trial Summary
This trial will develop a new MRI technique, called CATCH, to more accurately and quickly assess coronary artery disease.
Who is the study for?
The CATCH trial is for adults over 18 with a BMI under 30, who are either healthy volunteers without cardiovascular disease or patients stable after coronary artery disease diagnosis and treatment. It excludes those with MR imaging contraindications like certain implants, claustrophobia, severe allergies to animal dander, poor kidney function (GFR <45ml/min), or past reactions to gadolinium contrast.Check my eligibility
What is being tested?
CATCH aims to develop an MRI technique that enhances the evaluation of coronary atherosclerosis. The study will test this new method against traditional ones by comparing image quality and scanning efficiency. Participants may receive cardiac MRI scans using contrast agents and possibly beta blockers during the procedure.See study design
What are the potential side effects?
Potential side effects include discomfort from lying still during the MRI scan, breath-holding difficulties, reactions to contrast agents such as mild allergic symptoms or nausea, and less commonly anxiety due to claustrophobia.
CATCH Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ day 1
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Plaque to Myocardial Ratio (PMR).
Secondary outcome measures
Stenosis level (patient group only)
CATCH Trial Design
2Treatment groups
Experimental Treatment
Group I: Healthy VolunteersExperimental Treatment3 Interventions
Approximately 100 healthy male/female adult "normals" or "controls" will receive non-contrast or contrast-enhanced Cardiac MRI. Imaging may include administration of contrast and a beta blocker, based upon the focus of the study at the time of the scan, as well as the safety profile of the participant.
Group II: Coronary Artery Disease (CAD) PatientsExperimental Treatment3 Interventions
40 male/female adult outpatients who are suspected of having or have been diagnosed with coronary artery disease (CAD) will receive non-contrast or contrast-enhanced Cardiac MRI. Imaging may include administration of contrast and a beta blocker, based upon the focus of the study at the time of the scan, as well as the safety profile of the participant.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cardiac MRI
2017
Completed Phase 4
~3290
Contrast
2011
Completed Phase 2
~160
Beta blocker
2015
Completed Phase 4
~420
Find a Location
Who is running the clinical trial?
Cedars-Sinai Medical CenterLead Sponsor
502 Previous Clinical Trials
165,553 Total Patients Enrolled
22 Trials studying Coronary Artery Disease
17,287 Patients Enrolled for Coronary Artery Disease
Debiao Li, PhD4.950 ReviewsPrincipal Investigator - Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
3 Previous Clinical Trials
1,467 Total Patients Enrolled
1 Trials studying Coronary Artery Disease
333 Patients Enrolled for Coronary Artery Disease
5Patient Review
Dr. Li was kind, caring, and did a great job of keeping me informed. His surgical skill was excellent.
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You cannot have metal implants or be pregnant because they can interfere with the MRI scan.You cannot hold your breath for a short time or have a fear of small, enclosed spaces.You have a severe allergy to animal fur or have asthma triggered by animals.Your kidney function test doesn't meet the standard for getting an MRI with contrast, or you've had an allergic reaction to gadolinium-based contrast agents before.You have had four or more scans using a contrast dye called gadolinium.Healthy volunteers who are 18 years or older, not overweight, and have no history of heart problems.You are a man or woman over 18 years old and do not have suspected or diagnosed heart artery problems with stenting or bypass surgery.
Research Study Groups:
This trial has the following groups:- Group 1: Coronary Artery Disease (CAD) Patients
- Group 2: Healthy Volunteers
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the intake capacity for this clinical experiment?
"Affirmative. Clinicaltrials.gov states that the trial, which was initially posted on July 30th 2018 and recently revised on July 20th 2022, is presently searching for 140 participants from a single medical centre."
Answered by AI
What medical condition is this therapy normally employed to address?
"The central nervous system is typically treated with this particular drug, which has also proven effective in managing angina pectoris, myocardial infarction, and breast diseases."
Answered by AI
Are there any precedents to suggest the efficacy of this therapeutic approach?
"At the moment, there are 27 active studies investigating this therapeutic. 4 of these trials have advanced to Phase 3 and most sites can be found in Orlando, FL with a total of 183 locations conducting research into this intervention."
Answered by AI
Are there currently any vacancies in this clinical trial?
"Affirmative. Data featured on clinicaltrials.gov confirms that this scientific study, which was first posted on July 30th 2018, is actively recruiting participants. About 140 individuals need to be recruited from 1 trial site."
Answered by AI
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