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Neuroimaging for Sturge-Weber Syndrome

N/A
Recruiting
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
In children who will undergo formal neuropsychology testing including detailed language testing (age 3 years and above): proficiency of English language
No history of neurological or psychiatric disorder
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights

Study Summary

This trial is testing the accuracy of a new, rapid MRI approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS). The new imaging approach can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children). The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS.

Who is the study for?
This trial is for individuals aged 3 months to 30 years with Sturge-Weber syndrome (SWS) or at risk due to a facial port-wine birthmark. Healthy controls without neurological/psychiatric disorders can also join. Exclusions include metal in the body, pregnancy, MRI contrast sensitivity, renal disease, and severe claustrophobia.Check my eligibility
What is being tested?
The study tests a new rapid MRI technique that captures multiple images quickly without contrast agents and sedation. It aims to identify brain abnormalities in SWS patients and understand vascular/neuronal changes that could inform future interventions.See study design
What are the potential side effects?
There are no direct side effects from the non-invasive neuro-psychology testing or advanced brain MRI being used in this trial; however, some participants may experience discomfort or anxiety during the imaging process.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My child, who is 3 or older, speaks English well.
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I have no history of mental health or neurological conditions.
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I am between 3 months and 30 years old.
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I am between 3 and 30 years old.
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I am between 3 months and 30 years old with Sturge-Weber syndrome.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain
Correlation of diffusion tensor imaging (DTI) brain connectivity score with non-verbal IQ acquired within 1 day.
Correlation of diffusion tensor imaging (DTI) brain connectivity score with verbal IQ acquired within 1 day.
+1 more
Secondary outcome measures
Correlation of enlarged deep vein scores determined by magnetic resonance imaging (MRI) with motor scores acquired within 1 day.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with SWS or high-risk facial port-wine birthmarkExperimental Treatment2 Interventions
All patients with SWS brain involvement (based on previous imaging) or facial port-wine birthmark indicating a high risk for SWS brain involvement will undergo a brain MRI and neuro-psychology testing.

Find a Location

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
310 Previous Clinical Trials
109,016 Total Patients Enrolled
1 Trials studying Sturge-Weber Syndrome
250 Patients Enrolled for Sturge-Weber Syndrome
National Institutes of Health (NIH)NIH
2,720 Previous Clinical Trials
7,494,366 Total Patients Enrolled
3 Trials studying Sturge-Weber Syndrome
650 Patients Enrolled for Sturge-Weber Syndrome

Media Library

Brain Magnetic Resonance Imaging Clinical Trial Eligibility Overview. Trial Name: NCT04517565 — N/A
Sturge-Weber Syndrome Research Study Groups: Patients with SWS or high-risk facial port-wine birthmark
Sturge-Weber Syndrome Clinical Trial 2023: Brain Magnetic Resonance Imaging Highlights & Side Effects. Trial Name: NCT04517565 — N/A
Brain Magnetic Resonance Imaging 2023 Treatment Timeline for Medical Study. Trial Name: NCT04517565 — N/A
~11 spots leftby Feb 2025
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