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Stem Cell Regeneration for Gum Recession

N/A
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presence of periodontally healthy teeth at the recipient site
No previous harvesting procedure involving the palate
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at day 1 visit 1
Awards & highlights

Study Summary

This trial is investigating whether stem cells from different parts of the mouth have different ability to regenerate different kinds of tissue.

Who is the study for?
This trial is for English-speaking patients at the UAB Dental School with healthy teeth and gums who need a soft tissue graft due to mild to moderate gum recession. They must be able to maintain good oral hygiene, not be pregnant or breastfeeding, and not have had previous palate surgery.Check my eligibility
What is being tested?
The study aims to compare the regenerative abilities of mesenchymal stem cells taken from two areas in the mouth's roof (palate) - near the front (premolar) and back (molar). It will help optimize how these cells are used in repairing tissues like bone and gums.See study design
What are the potential side effects?
Since this trial involves harvesting cells rather than drug treatment, side effects may include discomfort or pain at the extraction site, bleeding, infection risk, swelling, and possible complications related to wound healing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My gums and teeth are healthy where I need treatment.
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I have never had tissue taken from the roof of my mouth.
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I need a gum graft for my teeth with mild to moderate recession.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at day 1 visit 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and at day 1 visit 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Osteogenic potential
Secondary outcome measures
Adipogenic potential
Genotype assay

Trial Design

2Treatment groups
Experimental Treatment
Group I: Progenitor Potential at Premolar siteExperimental Treatment1 Intervention
Harvested tissue from the front (premolar) part of the palate will be used to extract the gingival mesenchymal cells to test their progenitor potential to differentiate into multiple cell lineage.
Group II: Progenitor Potential at Molar siteExperimental Treatment1 Intervention
Harvested tissue from the back (molar) part of the palate will be used to extract the gingival mesenchymal cells to test their progenitor potential to differentiate into multiple cell lineage.

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,594 Previous Clinical Trials
2,282,459 Total Patients Enrolled

Media Library

progenitor potential of Gingival Mesenchymal cells Clinical Trial Eligibility Overview. Trial Name: NCT03570333 — N/A
Gum Recession Research Study Groups: Progenitor Potential at Molar site, Progenitor Potential at Premolar site
Gum Recession Clinical Trial 2023: progenitor potential of Gingival Mesenchymal cells Highlights & Side Effects. Trial Name: NCT03570333 — N/A
progenitor potential of Gingival Mesenchymal cells 2023 Treatment Timeline for Medical Study. Trial Name: NCT03570333 — N/A
~1 spots leftby May 2025
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