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Behavioral Intervention
Digital Therapeutics for Depression
N/A
Waitlist Available
Led By Lauren Oberlin, PhD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, mid-treatment (week 2), and post-treatment (week 4)
Awards & highlights
Study Summary
This trial tests a computer program to reduce apathy symptoms in people with depression, and see if it improves brain function, apathy, and cognitive performance.
Who is the study for?
This trial is for people over 60 with major depressive disorder and significant apathy, but no psychotic features. They must have a certain level of depression severity, be stable on antidepressants or other psychotropic meds for at least 8 weeks, and not plan to change doses soon. Participants need computer access, can follow instructions in English, are able to undergo MRI scans (no metal implants), and aren't at suicide risk or have serious medical/neurological conditions.Check my eligibility
What is being tested?
The study tests whether a custom digital cognitive training program can improve brain function related to apathy in older adults with depression. Over four weeks, participants will use this program aiming to reduce symptoms of apathy as well as enhance cognitive control performance.See study design
What are the potential side effects?
Since the interventions involve non-invasive digital cognitive exercises rather than medication or invasive procedures, side effects may include eye strain or headache from screen time; however specific side effects are not detailed in the provided information.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, mid-treatment (week 2), and post-treatment (week 4)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, mid-treatment (week 2), and post-treatment (week 4)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Resting State Functional Connectivity among the Salience, Executive Control, and Reward Networks
Secondary outcome measures
Change in Apathy Evaluation Scale (AES) score
Change in Stroop Interference score
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Targeted Cognitive Training InterventionExperimental Treatment1 Intervention
Group II: General Cognitive Training InterventionActive Control1 Intervention
Find a Location
Who is running the clinical trial?
National Institute of Mental Health (NIMH)NIH
2,789 Previous Clinical Trials
2,690,346 Total Patients Enrolled
1 Trials studying Apathy
22 Patients Enrolled for Apathy
Weill Medical College of Cornell UniversityLead Sponsor
1,055 Previous Clinical Trials
1,316,214 Total Patients Enrolled
Lauren Oberlin, PhDPrincipal InvestigatorWeill Medical College of Cornell University
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have not had electroconvulsive therapy in the last year.I can sign and understand the consent form for the study.I am currently in a cognitive rehabilitation program.I've been on a stable dose of antidepressants for 8 weeks and don't plan to change it.I am 60 years old or older.I have or had a serious brain or nerve condition like Alzheimer's, MS, or epilepsy.I have been on a stable dose of my mental health medication for at least 8 weeks.I am not taking any psychoactive drugs that could affect the study, except for antidepressants or benzodiazepines.I have been diagnosed with major depression without psychosis.I do not have any severe health conditions that could affect my participation in the study.I will not travel for 2+ weeks in a row during the study, preventing MRI data collection.
Research Study Groups:
This trial has the following groups:- Group 1: Targeted Cognitive Training Intervention
- Group 2: General Cognitive Training Intervention
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this research endeavor actively seeking participants at this time?
"The information hosted on clinicaltrials.gov confirms that this medical trial is not actively recruiting patients at the moment. This study was initially posted on August 1st 2023 and further updated by May 17th 2023; however, there are 888 other trials still searching for participants around the world presently."
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