← Back to Search

Behavioral Intervention

Aerobic Exercise for Depression

N/A

Recruiting

Research Sponsored by The Royal's Institute of Mental Health Research

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, mid-intervention (6 weeks), post-intervention (12 weeks), 3-month follow-up, 6-month follow-up

Awards & highlights

Study Summary

This trial will compare the effects of moderate vs. high intensity aerobic exercise on depression, cognition, and brain function in young adults.

Who is the study for?

This trial is for young people aged 16-24 who are struggling with depression and haven't been taking antidepressants or exercising regularly. They should be able to understand English, have a BMI under 40, and be medically okay to do aerobic exercise. Those at risk of suicide, with MRI issues, serious health conditions, nicotine use, pregnancy/breastfeeding or other major psychiatric disorders can't join.Check my eligibility

What is being tested?

The study is looking at how different levels of workout intensity affect depression in youth. Participants will do either moderate or high-intensity aerobic exercises three times a week for twelve weeks while being watched over by professionals to see changes in their mood, thinking skills and brain function.See study design

What are the potential side effects?

While the trial itself doesn't involve medication that could cause side effects, exercise may lead to muscle soreness, fatigue or injury if not done properly. The staff will supervise sessions to minimize risks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, mid-intervention (6 weeks), post-intervention (12 weeks), 3-month follow-up, 6-month follow-up

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, mid-intervention (6 weeks), post-intervention (12 weeks), 3-month follow-up, 6-month follow-up

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, mid-intervention (6 weeks), post-intervention (12 weeks), 3-month follow-up, 6-month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adherence to moderate & high intensity exercise regimens as prescribed

Changes in clinician-rated depression-related symptoms

Changes in self-reported depression-related symptoms

+2 more

Secondary outcome measures

Changes in cognitive function

Changes in daily functioning

Changes in electrocortical-indexed brain activity profiles

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Moderate IntensityExperimental Treatment1 Intervention

Aerobic exercise maintained for 30 minutes at 50-55% of each participant's individual heart rate reserve (HRRes).

Group II: High IntensityExperimental Treatment1 Intervention

Aerobic exercise maintained for 30 minutes at 80-85% of each participant's individual heart rate reserve (HRRes).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aerobic Exercise

2020

Completed Early Phase 1

~1340

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

The Royal's Institute of Mental Health ResearchLead Sponsor

4 Previous Clinical Trials

1,110 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What ultimate goals are investigators hoping to accomplish with this trial?

"This clinical trial will span several checkpoints, including Baseline, Mid-Intervention (6 weeks), Post-Intervention (12 weeks), 3-month follow-up and 6 month follow up. The investigation's primary objective is to measure shifts in depression related symptoms as reviewed by clinicians. Secondary outcomes are changes to cognitive function evaluated with the NIH Cognitive Toolbox; a compilation of seven computerised tests designed to assess multiple intellectual capacities. This data will then be combined for analysis. Additionally, self mastery appraisals using Perlin/Schooler’s Mastery Scale - a 7 item questionnaire - along with neuroimaging indexed brain activity"

Answered by AI

Are there any limits on the number of participants enrolling in this experiment?

"Correct. According to the information stored on clinicaltrials.gov, this trial is actively seeking out 40 participants from a single medical centre. The study was initially posted on August 7th 2018 and has since been updated as recently as May 2nd 2022."

Answered by AI

To what demographic is this experiment open?

"This study is seeking around 40 individuals with depression aged between 16 and 24. Those who meet these requirements may be accepted in the trial."

Answered by AI

Is there an age requirement to be eligible for this medical trial?

"Based on the inclusion criteria, this study is open to individuals aged 16 to 24. There are 177 clinical trials that focus specifically on minors and 848 dedicated to those over 65 years old."

Answered by AI

Are there any open opportunities to participate in this research?

"Clinicaltrials.gov states that this experiment is currently searching for study participants, with the original posting taking place on August 7th 2018 and most recent edits occurring May 2nd 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth

Dr. Natalia Jaworska 2018. "Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04110041.

All > Depression > Treatment Resistant Depression