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Dietary Supplement

Creatine Monohydrate Supplementation for Cardiac Function and Hemodynamics

N/A
Recruiting
Research Sponsored by Radford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Males
Aged 55-80 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and day 8.
Awards & highlights

Study Summary

This trial aims to see how taking creatine supplements by itself or along with moderate exercise affects the blood vessels and heart function in older men.

Who is the study for?
This trial is for men aged between 55 and 80, with no exclusions based on race, ethnicity, or socioeconomic status. It's designed to explore how creatine affects heart function and blood flow in the elderly.Check my eligibility
What is being tested?
The study tests if taking creatine monohydrate alone or combined with moderate exercise can improve vascular reactivity (how blood vessels respond to changes) and heart hemodynamics (blood flow through the heart).See study design
What are the potential side effects?
Potential side effects of creatine supplementation may include muscle cramping, nausea, diarrhea, dizziness, gastrointestinal pain, dehydration, weight gain due to water retention.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am male.
Select...
I am between 55 and 80 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and day 8.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and day 8. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in brachial-ankle pulse wave velocity (baPWV)
Secondary outcome measures
Cardiac Index
Contractility Index
Ejection Fraction
+2 more

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Creatine Monohydrate SupplementationExperimental Treatment1 Intervention
Blinded subjects are instructed to ingest 20g of creatine monohydrate for 7 days divided into 4 dosages of 5g each that should be taken with water or other liquids throughout the day (breakfast, lunch, afternoon and evening).
Group II: ControlActive Control1 Intervention
Participants in the control group do not receive a supplement (creatine or placebo) to ingest over the 7 day period.
Group III: Maltodextrin SupplementationPlacebo Group1 Intervention
Blinded subjects are instructed to ingest 20g of maltodextrin for 7 days divided into 4 dosages of 5g each that should be taken with water or other liquids throughout the day (breakfast, lunch, afternoon and evening).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Creatine Monohydrate
2009
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Radford UniversityLead Sponsor
5 Previous Clinical Trials
167 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Cardiac and Vascular Responses to Creatine Supplementation in Elderly Men
Adrian Aron 2022. "Cardiac and Vascular Responses to Creatine Supplementation in Elderly Men". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05329480.
~0 spots leftby Jun 2024
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