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Opioid Agonist/Antagonist

Buprenorphine/Naloxone for Postoperative Pain

Phase 4
Waitlist Available
Led By Yi Zhang, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 6 days
Awards & highlights

Study Summary

This trial looks at whether buprenorphine/naloxone (bup/nx) can help manage postoperative pain in people who have developed a tolerance to opioids.

Eligible Conditions
  • Postoperative Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 6 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 6 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Length of Hospital Stay
Postoperative Opioid Consumption
Postoperative Pain Scores

Trial Design

2Treatment groups
Active Control
Group I: Buprenorphine/NaloxoneActive Control1 Intervention
Subjects will take a maximum dose of 4 mg buprenorphine and 1 mg naloxone with concurrent administration of other intravenous or oral opioids needed.
Group II: Standard Medication RegimentActive Control1 Intervention
Subjects will take conventional intravenous or oral opioid management.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,941 Previous Clinical Trials
13,200,609 Total Patients Enrolled
3 Trials studying Postoperative Pain
260 Patients Enrolled for Postoperative Pain
Yi Zhang, MD, PhDPrincipal InvestigatorMassachusetts General Hospital
1 Previous Clinical Trials
23 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients
Yi Zhang, MD 2022. "Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04771689.
All > Probuphine
~21 spots leftby May 2025
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