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Curcumin for Breakthrough Bleeding

Phase 4
Waitlist Available
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1 to day 30
Awards & highlights

Study Summary

This trial will study the effects of curcumin on women who experience irregular bleeding while using the contraceptive implant.

Who is the study for?
This trial is for English-speaking women aged 15-45 who have been using a contraceptive implant for at least 30 days and are experiencing irregular bleeding. They must not be pregnant, breastfeeding, or have had certain cancers, and should not be on other conflicting medications.Check my eligibility
What is being tested?
The study is testing if curcumin (from turmeric) can help manage irregular bleeding in women using contraceptive implants compared to a placebo. Participants will report their bleeding patterns daily via text or email.See study design
What are the potential side effects?
While the trial's description doesn't list specific side effects of curcumin, common ones may include stomach upset, nausea, dizziness, or diarrhea. The placebo is unlikely to cause any side effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1 to day 30
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 to day 30 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total number of amenorrhea days
Secondary outcome measures
Number of consecutive bleeding-free days
Time (days) to stop bleeding
Total number of bleeding days
+2 more
Other outcome measures
Patient satisfaction with bleeding pattern as assessed by VAS
Proportion of participants who intend to continue use of implant

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Curcumin groupExperimental Treatment1 Intervention
Curcumin 600 mg (oral) once daily for 30 days to be started following 3 consecutive days of bleeding
Group II: Placebo groupPlacebo Group1 Intervention
Placebo (oral) once daily for 30 days to be started following 3 consecutive days of bleeding
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Curcumin
FDA approved

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
978 Previous Clinical Trials
7,386,446 Total Patients Enrolled
3 Trials studying Bleeding
167 Patients Enrolled for Bleeding
Merck Sharp & Dohme LLCIndustry Sponsor
3,899 Previous Clinical Trials
5,062,804 Total Patients Enrolled
1 Trials studying Bleeding
90 Patients Enrolled for Bleeding

Media Library

Curcumin (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04205929 — Phase 4
Bleeding Research Study Groups: Placebo group, Curcumin group
Bleeding Clinical Trial 2023: Curcumin Highlights & Side Effects. Trial Name: NCT04205929 — Phase 4
Curcumin (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04205929 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment for this research endeavor still in progress?

"Affirmative. Clinicaltrials.gov maintains that this clinical trial, first posted on April 15th 2020 is currently recruiting patients. The protocol calls for the recruitment of 58 individuals from a single medical site."

Answered by AI

Are participants aged below 25 years of age allowed to join this trial?

"According to the enrollment conditions for this study, interested parties must be between 15 and 45 years of age."

Answered by AI

Have there been any other investigations into the efficacy of Curcumin?

"Currently, 17 clinical trials are taking place to assess the utility of Curcumin. Out of these studies, three have reached Phase 3 and many of them are concentrated in Farmington Hills, Michigan with an overall total of 21 sites across America."

Answered by AI

Are there potential adverse effects of using Curcumin therapeutically?

"Leveraging the data from a Phase 4 trial, our team assigns Curcumin an assessment score of 3 to signify its approval for use."

Answered by AI

How many participants are enrolled in this medical investigation?

"Indeed, the particulars on clinicaltrials.gov points out that this study is presently searching for test subjects. It was first advertised to the public on April 15th 2020 and its parameters were most recently adjusted on September 22nd 2022. Currently, 58 individuals are being sought at a single medical facility."

Answered by AI

Am I eligible to take part in this clinical trial?

"Eligibility for this trial is contingent on a patient's age being between 15 and 45, as well as their presenting symptoms of bleeding. There are 58 spots available in total."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users
Alison Edelman 2020. "Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04205929.
~11 spots leftby May 2025
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