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EVH + Mannitol for Cough Variant Asthma
Study Summary
This trial will help determine if Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) can help individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH).
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I cannot perform a lung function test properly.I have had a chronic cough for over 8 weeks and it improved with asthma treatment.I've had a health issue in the last month that required changing my medication or a hospital visit.I am between 18 and 65 years old and have had a stroke or cough caused by methacholine with normal airway sensitivity.I have had a cough for over 8 weeks and passed a specific breathing test.You have medical reasons that make it unsafe for you to do the methacholine challenge test.I have smoked more than 10 pack-years.I am between 18 and 65 years old and have never had asthma or a chronic cough.
- Group 1: Control
- Group 2: Cough Variant Asthma
- Group 3: Methacholine-induced cough
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many individuals are being enrolled in this experiment?
"Yes, the information on clinicaltrials.gov indicates that this trial is actively looking for patients to enroll. The trial was posted on March 1st, 2022 and updated April 18th, 2022. Only 30 patients are needed at one site."
Are there any other similar studies that have been done on Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS)?
"There is currently one clinical trial ongoing that is researching the effects of Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) Challenge Tests. This study is in Phase 3 with several more trials being conducted in Kingston, Ontario."
Are researchers only looking for test subjects who are legal adults?
"The age limit for participants in this clinical trial is 65 years old. All patients that are hoping to enroll must be over the age of 18."
Are patients still being accepted for enrollment in this research project?
"Yes, this information can be found on clinicaltrials.gov. The study was posted on March 1st and updated April 18th of this year."
Are there any specific requirements to be a part of this research project?
"This trial is open to patients that have asthma and are between 18-65 years old. They are looking for around 30 participants in total."
Do these two types of tests, Eucapneic Voluntary Hyperventilation and Hypertonic Saline Challenge Tests, have FDA approval?
"EVH and HS have both been approved, meaning that these challenge tests are safe."
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