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Vasopressor Agent

Angiotensin II for Septic Shock

Phase 4
Waitlist Available
Led By Alexander H Flannery, Pharm.D.
Research Sponsored by Alexander Flannery
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 months following enrollment
Awards & highlights

Study Summary

This trial is testing if angiotensin II, a new FDA approved vasopressor agent, could help improve survival rates of septic shock patients, specifically those requiring continuous renal replacement therapy, those with altered angiotensin I: angiotensin II ratios, and those with elevated renin levels.

Eligible Conditions
  • Septic Shock
  • Acute Kidney Injury

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 months following enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 months following enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Plasma Renin Levels
Secondary outcome measures
Change in Renal Biomarkers
ICU Length of Stay
In-hospital mortality
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Angiotensin II CohortExperimental Treatment1 Intervention
Patients in this group will receive angiotensin II.
Group II: Standard of Care CohortActive Control1 Intervention
Patients in this group will receive standard of care treatment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Angiotensin II
2010
Completed Phase 4
~260

Find a Location

Who is running the clinical trial?

Alexander FlanneryLead Sponsor
1 Previous Clinical Trials
56 Total Patients Enrolled
Alexander H Flannery, Pharm.D.Principal InvestigatorUniversity of Kentucky
~7 spots leftby Jun 2025
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