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Methylphenidate for Post-Traumatic Stress Disorder
Study Summary
This trial will test how well methylphenidate (MPH) works in treating PTSD symptoms in veterans with comorbid ischemic stroke.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2020 Phase 4 trial • 267 Patients • NCT02039908Trial Design
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Who is running the clinical trial?
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- The traumatic event that caused PTSD happened during adulthood before having a stroke.Your total score on the CAPS-5 test from the past week is 27 or higher during the initial visit.You are diagnosed with post-traumatic stress disorder (PTSD) using the MINI International Neuropsychiatric Inventory (MINI) for DSM-5.You have a high risk of suicidal thoughts or behavior that requires hospitalization or extra treatment.You are currently taking part in another study for PTSD or stroke.I am currently in psychotherapy and can continue it during the study.You have had a serious head injury in the past, as determined by a specific method used to identify traumatic brain injuries.I have completed a PTSD therapy program before joining the study.You are not currently seeking legal compensation for a mental health condition. Veterans applying for or receiving VA service-connected disability are allowed.I had my first stroke, confirmed by scans, between 1 to 12 months ago.I am using birth control and am not pregnant or planning to become pregnant or breastfeed during the study.I haven't taken any experimental drugs or specific medications in the last 2 weeks.I had difficulty with daily activities before my stroke.You have had a serious allergic reaction to any form of MPH (a type of medication).I don't have any health issues that would make it unsafe for me to use MPH.I am willing to stop taking antipsychotics, mood stabilizers, stimulants, and any form of MPH.You have significant problems with memory and thinking, as shown by a specific test score.You have any conditions that would make it unsafe for you to have a standard MRI scan.I have been diagnosed with a specific mental health condition like bipolar disorder or schizophrenia.You have been diagnosed with a serious problem with drugs or alcohol (except for caffeine and nicotine) in the last 3 months.
- Group 1: Placebo
- Group 2: Methylphenidate
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What other research has been done on Methylphenidate's effect?
"At the moment, there are 30 clinical trials being conducted to research Methylphenidate. Out of those active studies, 2 have reached Phase 3. The majority of the research is based in Lexington, Kentucky; however, 43 different locations are running trials for this treatment."
Is Methylphenidate known to have harmful side effects?
"Methylphenidate has received a score of 2. This is because, although there is data supporting its safety, none exists yet for efficacy in humans."
How many people are being given the chance to participate in this experiment?
"That is correct. The information available on clinicaltrials.gov affirms that this study is still recruiting patients. This trial was first posted on January 14th, 2022 and was edited last on January 18th, 2022. Currently, the plan is to have 60 participants across 1 site."
Are people still being recruited to participate in this clinical trial?
"The trial, which can be found on clinicaltrials.gov, is looking for patients at the moment. The listing was put up on January 14th and updated on January 18th of this year."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
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