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Chemoradiation + Pembrolizumab/Olaparib for Small Cell Lung Cancer
Study Summary
This trial will compare overall survival and progression free survival of two groups of patients with advanced solid tumors - those who receive concurrent chemoradiation therapy with pembrolizumab followed by pembrolizumab plus olaparib, and those who receive concurrent chemoradiation therapy alone.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I am currently being treated for an infection.I have been diagnosed with pure Small Cell Lung Cancer.I am not pregnant and will follow birth control advice during and after the study.I have a history of HIV, Hepatitis B, or active Hepatitis C.I have another cancer besides the one being studied that has needed treatment in the last 5 years.I have had lung inflammation that needed steroids.You are expected to live for at least 6 more months.I can provide a sample of my tumor before treatment starts.I have or might have a blood disorder like MDS or AML.I will not breastfeed during and for 4 months after the study if I receive Pembrolizumab, or for 1 week if I receive Olaparib.I have been treated with olaparib or another PARP inhibitor before.My organs are functioning well.I have an immune system disorder or have been on high-dose steroids or other immune-weakening medicines recently.I have been treated for an autoimmune disease in the last 2 years.I am not expected to need surgery to remove a tumor during the study.I am fully active or restricted in physically strenuous activity but can do light work.I will not donate sperm during and after the treatment for a specified period.You have at least one specific area of your tumor that can be measured according to certain guidelines.I have been treated with specific immune therapy for cancer.I have not had any treatment for my small cell lung cancer.My small cell lung cancer is in an early stage and can be treated with radiation.I am 18 years old or older.My scans show no signs of cancer spread.I have not had major surgery within the last 4 weeks, except for procedures to place a vascular access.You have a severe allergic reaction (Grade 3 or higher) to the study treatment or any of its ingredients.
- Group 1: Group C (Pembrolizumab and Olaparib Matching Placebos)
- Group 2: Group A - Pembrolizumab 200 mg
- Group 3: Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the usual reason that doctors recommend Standard Thoracic Radiotherapy?
"Standard Thoracic Radiotherapy, a type of cancer treatment, is most often used to treat malignant melanoma of the skin. However, it can also be used to manage other conditions, such as merkel cell cancer, recurrent cervical cancer, and refractory, relapsed mediastinal large b-cell lymphoma."
Is it legal to administer Standard Thoracic Radiotherapy?
"There is both historical data and recent data supporting the safety of Standard Thoracic Radiotherapy, so it received a score of 3."
Is this research project happening in multiple states?
"There are 29 sites participating in this clinical trial. The sites are located in cities including Houston, Montréal, and Trois-Rivieres. If you are considering participating in the trial, it is best to choose a location that is nearest to you to minimize travel demands."
What other medical studies have been completed that use Standard Thoracic Radiotherapy?
"As of now, there are 1588 distinct clinical trials researching Standard Thoracic Radiotherapy. Of those, 280 are in Phase 3. Most of the research for Standard Thoracic Radiotherapy is centered in Houston, Texas, but there are 71273 locations running trials for this treatment globally."
Does this research project have any current openings for participants?
"This is accurate. The aforementioned website lists this trial as currently looking for participants. This study was initially posted on December 8th, 2020, and was most recently edited on November 7th, 2022. A total of 672 patients will be enrolled at 29 different hospitals."
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