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ACE Inhibitors for Lupus
Study Summary
This trial is testing if the drug lisinopril can help people with lupus by decreasing metabolism in the brain and improving cognitive function.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I haven't taken any experimental drugs recently.I am taking a low dose of steroids, not more than the equivalent of 10 mg of prednisone daily.I am between 18 and 65 years old.I am a diabetic patient currently using aliskiren.I have thoughts of harming myself or have been very depressed.I am currently being treated with Cyclophosphamide.I have been using pain medication regularly for more than 3 weeks in the last 3 months.My lupus symptoms have worsened recently, leading to a change in my medication.I understand the study and can give my consent.I do not have any active infections needing antibiotics or chronic infections like hepatitis or HIV.My disease has been stable without needing more medicine for the last 4 weeks.I have been taking specific blood pressure medication for over 4 weeks in the past year.I am not taking any mental health drugs except for SSRIs or gabapentin.I have started new medications for my condition within the last 3 months.I have had a mini-stroke in the last 6 months.I have no history of severe neurological diseases or brain injuries.I do not have uncontrolled severe high blood pressure, diabetes, or heart disease.My kidney function is reduced with an eGFR below 60%.I am currently taking naltrexone or minocycline regularly.
- Group 1: CA-ACEi
- Group 2: nonCA-ACEi
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is there an age cut-off for partaking in this research study?
"According to the criteria listed alongside this clinical trial, participants must be of legal age (18+) and not exceed 55 years old."
What is the geographical scope of this research effort?
"This medical trial can be done at 6 different hospitals, including Bronx Lebanon Hospital in Bronx and Andrew Shaw in Manhasset. Additionally, Northwell Rheumatology in Great Neck is another viable option, with three other sites available."
Can you provide an assessment of the security afforded by CA-ACEi?
"Although CA-ACEi has yet to be proven effective, the existing data on its safety is sufficient enough to rate it a score of 2."
Are there vacancies for persons to participate in this clinical experiment?
"Per the clinicaltrials.gov website, this clinical research is currently recruiting participants; it was initially posted on October 1st 2021 and was last updated November 15th 2021."
What criteria must a prospective participant meet to be eligible for this research?
"Candidates must have libman-sacks disease and be in the 18 to 55 age bracket to qualify for this medical research. The study is aiming to recruit 36 participants overall."
What is the total enrolment number for this trial?
"Affirmative. As per information on clinicaltrials.gov, the trial is actively recruiting participants after beginning to be posted on October 1st 2021 and having its most recent update occur on November 15th 2021. 36 patients must be enrolled from 6 different centres of care."
To what ailments is CA-ACEi commonly prescribed?
"CA-ACEi is a potential intervention for individuals with pre-existing conditions such as cardiovascular events, diabetic nephropathy and myocardial infarction."
Has the combination of CA-ACEi been tested in prior trials?
"Currently, 9 clinical trials related to CA-ACEi are being conducted. Two of these research studies have reached Phase 3 status with the majority taking place in Gainesville, Florida and a further 702 sites running associated trials."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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