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Antipsychotic

Olanzapine for Cancer

Phase 3
Waitlist Available
Led By Charles L Loprinzi
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 28 days
Awards & highlights

Study Summary

This trial is testing if olanzapine can help reduce nausea and vomiting in patients with advanced cancer.

Eligible Conditions
  • Cancer
  • Blood Cancers

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Nausea
Secondary outcome measures
Daily episodes of vomiting/retching (number and time)
Daily nausea and vomiting scores
Incidence of adverse events with olanzapine
+1 more

Side effects data

From 2008 Phase 4 trial • 25 Patients • NCT00001656
31%
Increased appetite
31%
Hypersalivation
17%
tachycardia >100 beats/min (supine)
15%
Somnolence
15%
Constipation
9%
Hypertension
8%
Difficulty concentrating
8%
Insomnia
8%
Enuresis
8%
Abnormal white blood count
100%
80%
60%
40%
20%
0%
Study treatment Arm
Olanzapine Group
Clozapine Group

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (olanzapine)Experimental Treatment2 Interventions
Patients receive olanzapine PO every night on days 1-28.
Group II: Arm II (placebo, olanzapine)Active Control3 Interventions
Patients receive placebo PO every night on days 1-2 and olanzapine PO every night on days 3-28.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Olanzapine
2005
Completed Phase 4
~5480

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,718 Previous Clinical Trials
40,963,391 Total Patients Enrolled
Mayo ClinicLead Sponsor
3,245 Previous Clinical Trials
3,783,452 Total Patients Enrolled
Charles L LoprinziPrincipal InvestigatorMayo Clinic in Rochester
3 Previous Clinical Trials
63 Total Patients Enrolled
~0 spots leftby May 2025
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