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CAB-AXL-ADC + PD-1 Inhibitor for Sarcoma
Study Summary
This trial is testing a new cancer drug to see if it is safe and effective.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I do not have uncontrolled brain metastases.I have never had a severe allergic reaction to monoclonal antibody therapy.I am fully active or restricted in physically strenuous activity but can do light work.I have not had major surgery in the last 4 weeks.I have never been treated with auristatin or vinca-binding site targeting drugs.I do not have HIV, active hepatitis B, or hepatitis C.I am 12 years old or older.My kidneys are working well.My blood counts are within a healthy range.I do not have any serious heart conditions.I am not pregnant or breastfeeding.My liver is working well.
- Group 1: BA3011
- Group 2: Combination Therapy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there numerous hospitals administering this trial throughout the nation?
"Currently, this trial is taking place in 28 different locations. Some of these sites are situated in Los Angeles, Columbus and Durham; however, there are also 25 other clinical centres running this study. If you enroll, it would be advantageous to choose the nearest location to cut down on travel time."
How many people are the most that will be taking part in this experiment?
"The sponsor, BioAtla, Inc., needs to recruit 120 eligible patients from clinical trial sites that include Children's Hospital Los Angeles and Nationwide Children's Hospital."
Are we able to sign new patients up for this clinical trial right now?
"Yes, this study is still recruiting patients. It was originally posted on February 15th, 2018, and the most recent update was on October 5th, 2022."
What is the main focus of this clinical trial?
"The aim of this 24-month clinical trial is to evaluate BA3011's anti-tumor activity. Additionally, researchers will be looking at the drug's pharmacokinetics (AUC), immunogenicity, and overall survival rate in Phase 1 and 2 patients."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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