Extended-Release Naltrexone + Buprenorphine for Cocaine Use Disorder (CURB-2 Trial)

"This medical trial is only for adults aged between 18 and 65; minors have 260 studies available to them, whereas seniors can choose from 653 research programs."

"Our team has rated the safety of Drug Intervention (XR-NTX+ XR-BUP) to be a 2, as this is only at Phase 2. That means that while there have been some studies into its security, none yet support efficacy."

"Indeed, the information on clinicaltrials.gov reveal that this study is accepting participants. This research endeavor was first posted on March 14th 2023 and last updated on May 2nd 2023; it seeks to recruit 426 patients from two distinct locations."

"Affirmative. The details available on clinicaltrials.gov demonstrate that this medical investigation is currently enrolling applicants, with the protocol first uploaded on March 14th 2023 and most recently modified on May 2nd 2023. A total of 426 individuals need to be recruited between two distinct locations."

"This medical trial requires 426 participants with cocaine use disorder who meet the following conditions: aging between 18 and 65 years, expressing an interest in decreasing or discontinuing their consumption of cocaine, adhering to DSM-5 criteria for moderate/severe CUD (4+ symptoms), providing two urine samples that test positive for cocaine within a 10 day window over 21 days during screening, detailing their past 30-day usage on the Timeline Follow-Back questionnaire, contracepting if female unless incapable of conceiving naturally (e.g., hysterectomy or postmenopause), delivering a sample devoid of opioids as well as declaring no"