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Radiation Therapy

Group 1: 10 Gy Low-KV IORT for Pancreatic Cancer (IORT Trial)

Phase 1

Waitlist Available

Research Sponsored by Loyola University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 52 weeks

Awards & highlights

IORT Trial Summary

This trial is testing whether adding radiation therapy to surgery helps people with pancreatic cancer live longer.

Eligible Conditions

Pancreatic Cancer

IORT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 52 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~52 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 52 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Maximum Tolerated Dose

Secondary outcome measures

Diet Surveys

IORT Trial Design

3Treatment groups

Experimental Treatment

Group I: Group 3: 20 GY Low-KV IORTExperimental Treatment1 Intervention

20 GY Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 20 Gy at 2 millimeter depth. Patients will be accrued to this group until the DLT is reached and MTD is realized.

Group II: Group 2: 15 Gy Low-KV IORTExperimental Treatment1 Intervention

15 Gy Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 15 Gy at 2 millimeter depth. Doses will be escalated in increments of 5 Gy until completion of 20 Gy dose level or the DLT is reached and MTD is realized.

Group III: Group 1: 10 Gy Low-KV IORTExperimental Treatment1 Intervention

10 Gy Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 10 Gy at 2 millimeter depth. Doses will be escalated in increments of 5 Gy until completion of 20 Gy dose level or the DLT is reached and MTD is realized.

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Who is running the clinical trial?

Loyola UniversityLead Sponsor

156 Previous Clinical Trials

30,922 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What possible risks are associated with this treatment?

"Due to the limited data backing both safety and efficacy, our team has assigned this treatment a score of 1 out of 3."

Answered by AI

To what capacity is this clinical trial recruiting participants?

"Indeed. The clinical trial hosted on clinicaltrials.gov shows that this study is presently recruiting participants, with the first posting having been placed on January 1st 2015 and last updated June 3rd 2020. Henceforth, twelve patients are required to be recruited from one medical centre."

Answered by AI

Have enrollment slots opened for this clinical experiment?

"Affirmative. Per the clinicaltrials.gov website, this study is currently enlisting patients for participation. It was initially published on January 1st 2015 and most recently updated June 3rd 2020. The trial requires 12 enrollees from a single location to complete it's goals."

Answered by AI

Recent research and studies

Archives of SurgeryJournal

Pancreatic Cancer

Kaiser, Martin H.. 1985. “Pancreatic Cancer”. Archives of Surgery. American Medical Association (AMA). doi:10.1001/archsurg.1985.01390320023003.

CA: A Cancer Journal for CliniciansJournal

Cancer Statistics, 2013

Siegel, Rebecca, Deepa Naishadham, and Ahmedin Jemal. 2013. “Cancer Statistics, 2013”. CA: A Cancer Journal for Clinicians. Wiley. doi:10.3322/caac.21166.

formation/NLM/NIH, NCBI. “Gprobe”. 2017. Web. <https://github.com/ncbi/gprobe>..Journal

Gprobe

Information/NLM/NIH, NCBI. 2017. “Gprobe”. GitHub repository. https://github.com/ncbi/gprobe.

Archives of SurgeryJournal