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Corticosteroid

Corticosteroid + Anesthetic Injection for Knee Osteoarthritis (Injections Trial)

Phase 1
Recruiting
Research Sponsored by Foundation for Orthopaedic Research and Education
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 84 post procedure (through edc)
Awards & highlights

Injections Trial Summary

This trial will compare pain relief from corticosteroid injections with & without anesthetic & with varying anesthetic amounts. Pain relief and tolerance will be measured post-procedure.

Who is the study for?
This trial is for adults over 18 with moderate osteoarthritis (Kellgren Lawrence Stage II or III) who can give consent. It's not suitable for those outside this group.Check my eligibility
What is being tested?
The study tests pain relief from corticosteroid injections, both with and without anesthetic, in knee osteoarthritis patients. Pain levels are tracked over time to see how long relief lasts and how well different mixtures work.See study design
What are the potential side effects?
Possible side effects may include discomfort at the injection site, potential allergic reactions to the medications used, and varying responses to pain relief.

Injections Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 84 post procedure (through edc)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 84 post procedure (through edc) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Injection for Knee Pain
Secondary outcome measures
Assessment of Knee Pain
Other outcome measures
Medications
Review of Adverse Events

Injections Trial Design

3Treatment groups
Experimental Treatment
Group I: Kenalog with 4ml bupivacaineExperimental Treatment1 Intervention
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,4ml of bupivacaine. The patients will be randomized into this group.
Group II: Kenalog with 0ml bupivacaineExperimental Treatment1 Intervention
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,0ml of bupivacaine. The patients will be randomized into this group.
Group III: Kenalog with 0.25% bupivacaineExperimental Treatment1 Intervention
The intervention in this study is one intra-articular knee injection of synthetic corticosteroid (kenalog) and variable amount of anesthetic,0.25% of bupivacaine. The patients will be randomized into this group.

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Foundation for Orthopaedic Research and EducationLead Sponsor
13 Previous Clinical Trials
1,007 Total Patients Enrolled
Florida Orthopaedic InstituteNETWORK
8 Previous Clinical Trials
400 Total Patients Enrolled

Media Library

Kenalog with bupivacaine Injection (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT05906433 — Phase 1
Osteoarthritis Research Study Groups: Kenalog with 0ml bupivacaine, Kenalog with 4ml bupivacaine, Kenalog with 0.25% bupivacaine
Osteoarthritis Clinical Trial 2023: Kenalog with bupivacaine Injection Highlights & Side Effects. Trial Name: NCT05906433 — Phase 1
Kenalog with bupivacaine Injection (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05906433 — Phase 1
~0 spots leftby Jun 2024
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