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ATM-Inhibitor + Radiation for Brain Tumor
Study Summary
This trial is testing a new drug to treat brain tumors that have come back after radiation therapy.
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Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am 18 years old or older.I am willing to protect myself from light during and two weeks after the study.I do not have any severe illnesses or social situations that would stop me from following the study's requirements.I have a long QT interval or risk factors for Torsades de Pointes.I haven't taken seizure medications or more than 8 mg of steroids daily in the last two weeks.I have had lung conditions that needed steroid treatment.I haven't had radiation in the last 6 months or recent drug treatments.I do not have uncontrolled high blood pressure, severe brain injury, or stroke, and I am not on any experimental treatments.I have not had a heart attack in the last 6 months and do not need ongoing therapy for severe heart rhythm problems.I am not willing to use birth control during the trial.I am in Group C, scheduled for brain surgery and targeted radiation as part of my treatment.My brain tumor is confirmed as Glioblastoma or Grade 3/4 astrocytoma.I can't control my nausea with medication, have chronic stomach issues, trouble swallowing pills, or had a major gut surgery affecting medicine absorption.I can take care of myself and perform daily activities.My glioma has worsened despite radiation and chemotherapy.I have a bleeding disorder or a history of significant bleeding.
- Group 1: Group B (Dose Expansion)
- Group 2: Group A (Dose Escalation)
- Group 3: Group C (Tumor Penetrance Treatments)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could you elucidate the primary aims of this trial?
"This study seeks to identify the optimal dosage of WSD0628 when paired with radiation therapy for patients suffering from recurrent high-grade glioma. Its primary measure of success is a period of 4 weeks following the last day of RT (extended up to 60 days). Secondary outcomes assessed include intracranial overall response rate, progression-free survival, and volumetric change in tumor size as measured by MRI/CT scan evaluations."
Is there an opportunity for volunteers to join this clinical investigation?
"According to clinicaltrials.gov, this medical trial is not presently recruiting patients. It was first listed on September 15th 2023 and its most recent update came through June 15th of the same year. Although no longer accepting enrollees, there are 835 other clinical trials actively seeking participants at present."
Has Group A (Dose Escalation) been granted sanction by the FDA?
"Due to the limited evidence of safety and efficacy available, our team at Power estimated Group A (Dose Escalation) to have a score of 1."
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