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Anti-metabolites
High-Dose Methotrexate for Breast Cancer
Recruiting1 awardPhase 2
Baltimore, Maryland
This trial is testing the use of high-dose methotrexate to treat leptomeningeal disease (LMD) in patients with metastatic breast cancer. LMD is a cancer that has spread to the thin layer of tissue that covers the brain and spinal cord. There is no cure for LMD, and it is a difficult disease to treat because it is hard to reach with traditional cancer treatments. HD-MTX is a chemotherapy drug that has been shown to be effective against breast cancer, and it is hoped that it will be effective against LMD as well. This study is being done to see if HD-MTX is
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