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IAP Antagonist
Birinapant + IMRRT for Head and Neck Cancer
Recruiting1 awardPhase 1
Orange, California
This trial is testing the side effects and best dose of birinapant given with IMRRT for head and neck squamous cell carcinoma that has come back. Birinapant may stop the growth of tumor cells by blocking IAP, a protein needed for tumor cell survival. IMRRT uses thin beams of radiation of different intensities that are aimed at the tumor from many angles. This type of re-irradiation therapy reduces the damage to healthy tissue near the tumor. Giving birinapant with IMRRT may lower the chance of head and neck squamous cell carcinoma growing or spreading.
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